The Essential Night Retinol Serum 2.5X is formulated with Retinoinâ„¢ Active Pro-Penetrant delivery system that activates a heightened level of retinization to the skin. Formulated with an age-defying pairing, All-trans-Retinol, and Bakuchiol help to improve the visible signs of aging and visibly reduce the incidence of redness or irritation.